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Careers


Welcome to Neon Therapeutics. Take a look at our available opportunities and if you see a position that piques your interest, send your resume to careers@neontherapeutics.com. In the subject line please note the position for which you are applying.

Current Openings


  • Neon Therapeutics, a new discovery and development stage company in the area of neoantigen biology and cancer immunotherapy is seeking a senior immunologist to establish and lead the laboratory efforts in this scientific arena. Neon is exploring both cancer vaccines and neoantigen-driven adoptive T cell therapies and has both ongoing research and clinical trials. The company has been established with significant support from Third Rock Ventures and scientific founders who are the foremost leaders in the field.

    Responsibilities:

    • Build the company’s immunology team, including Ph.D. Scientists and Research Associates.
    • Establish in-house immunology laboratory focusing on both research efforts and immune monitoring activities for the company’s ongoing clinical trials.
    • Apply research efforts to fundamental discovery in neoantigen biology, cancer vaccine design, and evaluation and establishment of T cell immunotherapy approaches
    • Translate recent advances in cancer vaccines and cancer immunotherapy to inform in-house programs.
    • Work with cancer immunology thought leaders to develop research plans.
    • Develop new biomarkers to assess immune responses.
    • Develop T cell immunization strategies.
    • Understand relevant animal models.
    • Coordinate academic collaborations.
    • Develop/optimize immunology assays in-house.

     

    Qualifications:

    • Ph.D. or M.D./ Ph.D. degree in Immunology.
    • 10-15 years of significant T cell experience; scientific expertise in the one or more of the following areas: T cell immunobiology, tumor immunology and/or cancer vaccines.
    • Strong scientific record of accomplishment as evidenced by publications in top journals is required.
    • Experience in industry and with a solid track record in cancer immunotherapy research and/or development is preferred.
  • We are seeking an innovative, collaborative and enthusiastic computational scientist to work on a variety of high-dimensional bioinformatics projects centered on target identification, drug discovery and translational research. The individual will integrate internal and external datasets, including next generation sequence data. The successful candidate will be one who can develop novel methods, analysis strategies and tools to filter and distill multi-dimensional datasets to generate focused hypotheses to drive primary research. A critical component of the job will be the close collaboration with multi-disciplinary internal discovery teams and external collaborators. This individual will be a critical thought leader in the company, collaborating closely with discovery and development scientists.

    Responsibilities:

    • Design and evaluate integrative approaches to the analysis of NGS cancer exome and transcriptome data, as well as other high-throughput data types.
    • Apply machine learning/statistical-based approaches to establish and benchmark predictive models of biological/chemical data.
    • Develop innovative, robust, analysis pipelines that can be applied in a research and clinical setting.
    • Develop and contribute to external collaborations and partnerships
    • Liaise with lab scientists and software engineers as a project team member and provide expertise as a scientific resource
    • Working knowledge of oncology and/or immunology preferred. Experience with planning of clinical trials a plus.

     

    Additional qualifications:

    • Ph.D. in bioinformatics, computational biology, genetics or a related discipline + 3-5 years’ experience of applied research in either an academic or industry setting.
    • Expertise in computational biology, genomics and other high throughput data platforms with an aptitude to apply experimental methods to understand disease biology and drug discovery
    • Significant experience in the analysis of high-throughput DNA and RNA high-throughput sequencing data, including alignment, quality measurements, variant calling, fusion discovery and transcript quantification.
    • Demonstrated ability to formulate and test hypotheses by designing and implementing computational approaches. Ability to effectively interpret and communicate conclusions from complex data is essential.
    • Capacity to prioritize and work independently complete tasks and advance projects with minimal supervision.
    • Ability to work effectively with internal and external collaborators and multidisciplinary teams composed of scientists and non-scientists to translate emerging research to guide internal programs
    • Identify partners/consultants to complement internal bioinformatics efforts.
    • Proficient written and verbal communication skills, particularly of complex information and concepts.
    • Creative, innovative thinking

     

    Other ideal areas of scientific expertise:

    • Fundamental statistics and machine learning applications to life sciences
    • Experience analyzing protein sequences
    • Predictive modeling, benchmarking
    • Experience with mining public data sets, such as TCGA,

     

    Technical proficiencies should include:

    • Linux in a grid and/or cloud environment. Experience with cloud computing preferred.
    • Proficient programming skills and computational analysis background.
    • Familiarity and experience applying statistical fundamentals
    • Experience with R, PERL or Python, SQL are highly desirable.
    • Distributed computing
  • Position Summary

    Neon is seeking a highly motivated Research Associate/Senior Research Associate to join Neon’s Biochemistry group. The candidate will work within the biochemistry group to support Neon’s inaugural personalized cancer vaccine trial NEO-PV-01 with critical protein reagents for downstream immunological assays. In addition, the candidate will help to develop new biochemistry technologies and assays in the field of antigen presentation.

     

    Job responsibilities include:

    • Expression of recombinant proteins in bacterial cells (E. coli) and protein purification by affinity, ion-exchange, size-exclusion chromatography. Characterization of protein purity, activity and yield. Develop and optimize expression systems and conditions.
    • Design and molecular cloning of protein constructs for expression, purification, and assay development (e.g. fusion proteins, mutations).
    • Protein refolding from inclusion bodies, high-throughput screening for folding conditions and biological activity.
    • Perform ELISA and other biochemical assasys.
    • Enzymatic labeling (biotinylation, fluorescent labeling) of proteins to generate and provide protein reagents to other departments for downstream assays.
    • Improvement of current processes and implementation of new technologies.
    • Analysis and presentation of results to larger scientific groups.
    • Work productively in a team environment and independently and deliver against timelines.
    • Keep very well documented electronic lab notebook.

     

    Experience and essential skills:

    • The candidate must have a BS/MS in biochemistry, biotechnology, biological science and 2+ years of relevant research experience.
    • Proficiency in protein purification techniques such as affinity, ion exchange, gel filtration.
    • Strong experience in protein characterization techniques such as SDS-PAGE, Western blot, ELISA, SEC is required.
    • Deep understanding and hands-on-experience in molecular cloning
    • Familiarity with Äkta purification and HPLC systems is preferred.
    • Excellent organizational, communication skills and a pro-active mentality.
    • Excellent attention to detail.
    • Ability to maintain inventories of equipment, supplies, and related research materials
    • Ability to effectively work on a team but also independently.

     

    Optional skills:

    • Broad understanding of cellular and molecular biology.
    • Basic understanding of immunology
    • Experience with bioanalytical techniques, such as DSF, SEC-MALS
  • Position Summary

    The successful candidate will be part of an exciting new start up that is designing experiments and optimizing assays with the goal of inducing T cell responses against neoantigens that are shared across patients and tumor types. As part of a multi-disciplinary team, you will work closely with biochemists, bioinformatics and the departments of peptide chemistry, molecular biology and immune monitoring to develop and assess efficacy of this approach.   This position reports to a Scientist, Cancer Immunology who is leading the program.

     

    Job responsibilities include:

    • Assessment of specificity and functionality of human T cells by multicolor flow cytometry
    • Analyze multicolor flow cytometry data
    • Molecular cloning and transduction of lentiviral or retroviral vectors
    • Cell culture of virally transduced T cells
    • Track and compile results in an electronic notebook
    • Assist with the training of lab personnel
    • Present results to other scientific teams

     

    Experience and Essential Skills:

    • BS or MS in immunology and/ or relevant experience in cancer immunology
    • A strong background in molecular biology, preferably in the context of immunology
    • 3+ years of relevant research experience
    • Demonstrated experience of flow cytometry and other T cell based assay development
    • Ability to work independently, as well as in a collaborative environment to meet project goals
    • Excellent attention to detail
    • Excellent written and oral communication skills
    • Enjoys solving challenging scientific questions in a fast pace environment
    • Independent, flexible, self-motivated, and the ability to work well with others
  • Position Summary

    The successful candidate will work on a program that aims to design novel personalized neo-antigen cancer immunotherapies. They will be responsible for participating in the development of immune cell-based assays. The candidate will need to effectively work in a team setting as well as independently optimize new technologies at high throughput.

    A successful candidate will be responsible for culturing multiple cell lines, flow cytometric cell profiling, generating lentivirus, and stable cell line generation and banking. The candidate will also need to be familiar with delivering mRNA to cells.

    Excellent written and spoken communication and organizational skills are required.

     

     

    Experience and essential skills:

    • BS., B.A., or M.S. degree in biology or relevant field
    • Strong background in cell biology and/or immunology.
    • Extensive cell culture experience.
    • 4+ years of relevant research experience.
    • Demonstrated mastery of flow cytometry and related data analysis.
    • Ability to organize cross-functional projects and tabulate data.
    • Excellent attention to detail.
    • Ability to maintain inventories of equipment, supplies, and related research materials.
    • Ability to effectively train other team members on techniques.
    • Strong written and oral communication skills.
    • Independent, flexible, self-motivated.
  • Position Summary

    The successful candidate will work on a program that aims to design novel personalized neo-antigen cancer immunotherapies. They will be responsible for participating in the development of novel high-throughput primary cell assays. The candidate will need to both effectively work on a team but also independently test many different developing technologies.

    Day-to-day responsibilities will include isolating and culturing primary immune cells, flow cytometric cell profiling, and basic molecular and protein biology methods including RNA isolation and Western blotting.

     

    Experience and essential skills:

    • B.S., B.A., or M.S. degree in biology or relevant field
    • Strong background in cell biology, molecular biology, biotechnology, and/or immunology.
    • Primary cell culture, preferably with primary immune cells.
    • Experience with basic molecular biology and biochemistry techniques.
    • 4+ years of relevant research experience.
    • Demonstrated mastery of flow cytometry and related data analysis.
    • Ability to organize and tabulate data.
    • Excellent attention to detail.
    • Ability to maintain inventories of equipment, supplies, and related research materials.
    • Excellent and record-keeping skills.
    • Strong written and oral communication skills.
    • Independent, flexible, self-motivated.
  • Position Summary

    Neon is seeking a highly-motivated Scientist to join Neon’s Biochemistry group. The candidate will work within the biochemistry group and in close collaboration other groups at Neon on a program that aims to design novel personalized neo-antigen based cancer vaccines. He/she will work independtly as well as part of a multi-disciplinary research team to develop different vaccine technologies.

     

    Job responsibilities include:

    • Expression of recombinant proteins in bacterial cells and protein purification by affinity, ion-exchange, size-exclusion chromatography and protein characterization.
    • Design and molecular cloning of protein constructs and protein engineering.
    • Perform biochemical assays to study protein interactions
    • Participate in the design, development and implementation of cell-based assays.
    • Improvement of current processes and implementation of new technologies.
    • Analysis and presentation of results to larger scientific groups.
    • Work productively in a team environment and independently and deliver against timelines.

     

    Experience and essential skills:

    • PhD in Biochemistry or related biological Science with 0 to 5 years of post-graduate working experience in academia or industry
    • Expert in protein biochemistry and proficiency in various protein purification techniques such as affinity, ion exchange, gel filtration.
    • Strong experience in protein characterization and bioanalytical techniques such as SDS-PAGE, Western blot, ELISA, SEC required.
    • Deep understanding of molecular biology and hands-on-experience in molecular cloning (e.g. Gibson assembly)
    • Knowledge of immunology and dendritic cell biology, and experience in cell culture work.
    • Demonstrated experience in complex problem solving and strong publication record.
    • Excellent organizational, communication skills and a pro-active mentality.
    • Excellent attention to detail.
    • Demonstrated experience functioning within a multi-disciplinary team and utilizing cross-functional information, such as immunology and vaccine development, to optimize the biochemical work flow;
    • Demonstrated experience working with contract research organizations and academic collaborators

     

    Optional Skills:

    Experience with protein bioanalytical methods like SEC-MALS and DLS are beneficial.

     

  • Position Summary

    Neon is seeking a highly-motivated Senior Research Associate to join Neon’s Immune monitoring group. The candidate will work within the Immune monitoring group in close collaboration with other scientists in the group and with other groups at Neon. The group is focused on translational immunology and he/she will work directly with the clinical samples generated during Neon Trials. He/she will work independently as well as part of a multi-disciplinary research team to develop different immune monitoring assays and data.

     

    Job responsibilities include:

    • Design and perform Immune Monitoring assays like ELISAs, ELISPOTS, Fluorescence activated cell sorting analysis, mass cytometry and T cell proliferation assays.
    • Purification and characterization of PBMCs and tumor infiltrating lymphocytes from peripheral blood and lymphocytes.
    • Establish and maintain primary human culture.
    • Develop SOPS and maintain a high standard of experimentation and record keeping
    • Will be an active player in clinical sample management and analysis.
    • Improvement of current processes and implementation of new technologies.
    • Analysis and presentation of results to larger scientific groups.
    • Work productively in a team environment and independently and deliver against timelines.

     

    Experience and essential skills:

    • BS/MS in Biological Science with a minimum of 5 years of working experience in academia or industry.
    • Expert in immunology and development of immune related assays.
    • Strong experience in FACS and prior experience in mass cytometry preferred.
    • Deep knowledge of T cell biology, and experience in cell culture work.
    • Prior experience working with immuno-oncology systems preferred.
    • Experience in a clinical lab highly desirable.
    • Demonstrated experience in complex problem solving.
    • Excellent organizational, communication skills and a pro-active mentality.
    • Excellent attention to detail.
    • Demonstrated experience functioning within a multi-disciplinary team and ability to integrate cross-functional information, to optimize work flows.
    • Demonstrated experience working with contract research organizations and academic collaborators.
  • Position Summary

    Neon is seeking a Research Associate to join Neon’s Peptide Chemistry group. The candidate will work within the Peptide group and in close collaboration other groups at Neon on several programs that aim to design novel personalized neo-antigen based cancer vaccines and support other in-house research efforts. He/she will work independently as well as part of a multi-disciplinary research team to synthesize neoantigen peptides identified by bioinformatics and clinical trial data. S/he will work both independently and cross-functionally to develop and test many different vaccine technologies.

     

    Job responsibilities include:

    • Synthesize and purify peptides using automated peptide synthesizers and purification systems to support the research and development of cancer vaccines
    • Manage chemical inventories, lab supplies, and maintain lab instruments
    • Contribute to the development and management of peptide database
    • Develop methods for high throughput peptide synthesis and purification
    • Work cross-functionally with analytical, quality, computational, and biology groups to achieve company objectives

     

    Experience and essential skills:

    • BS in organic chemistry or a related discipline; 2-3 years of industry experience in peptide synthesis and purification, a plus
    • Experience in solid phase synthesis, solid phase extraction, peptide synthesizers, and purification/analytical instruments including HPLC, UPLC, LC-MS, etc
    • Experience in flash purification techniques is desirable
    • Strong attention to detail
    • Excellent record keeping skills
    • Independent, self-motivated, and the ability to work well with others
  • Position Summary

    The successful candidate will work on a program that aims to design novel personalized neo-antigen cancer immunotherapies. They will be responsible for participating in the development of immune cell-based assays. The candidate will need to effectively work in a team setting to optimize new technologies at high throughput.

    A successful candidate will be responsible for culturing multiple cell lines, generating lentivirus, and stable cell line generation and banking.

    Excellent written and spoken communication and organizational skills are required.

     

    Experience and essential skills:

    • B.S., B.A., or M.S. degree in biology or relevant field
    • Strong background in cell biology and/or immunology.
    • 1-2 years of cell culture experience.
    • Ability to organize cross-functional projects and tabulate data.
    • Excellent attention to detail.
    • Ability to maintain inventories of equipment, supplies, and related research materials.
    • Strong written and oral communication skills.
    • Independent, flexible, self-motivated.

     

  • Position Summary

    Neon is seeking a highly-motivated Scientist to join the peptide chemistry department. The candidate will work within the analytical group and in close collaboration with peptide synthesis and other groups at Neon on programs that aim to develop novel personalized neoantigen based cancer vaccines. He/she will work independtly as well as part of a multi-disciplinary research team to purify and analyze peptides.

     

    Job responsibilities include:

    • Perform automated, mass-directed high throughput purification of peptides and peptide libraries at different scales using HPLC-MS systems
    • Develop analysis and purification methods and protocols
    • Develop automated analysis and purification processes
    • Implement LIMS in analysis, purification and compound registration
    • Perform downstream HPLC fraction work up, including fraction analysis, pooling and lyophilization
    • Analyze crude samples, HPLC fractions, and final products using UPLC-MS
    • Maintain analytical and purification instruments
    • Organize final products and QC data for compound registration
    • Work productively in a team environment and independently and deliver against timelines.

     

    Experience and essential skills:

    • A Ph.D. with more than 1 year industry experience, M.S. with more than 3 years of industry experience or B.S. with more than 5 years of experience in purification and analysis
    • Comprehensive knowledge and technical expertise in chromatographic separation and HPLC analysis
    • Strong experience in mass-directed purification with automated LC-MS systems
    • Hands on experience in HPLC trouble shooting and maintenance
    • Experience with UPLC-MS systems
    • Experience in using Masslynx and Empower software
    • Experience with automation and LIMS system is highly desirable
    • Excellent interpersonal and communication skills and a pro-active mentality
    • Highly organized with strong attention to details
    • Must be able to work in a team and collaborative environment

Core Values

At Neon, our core values act as a guidepost for our thoughts and behaviors.


Why do we come to work every day?

How do we approach our work?

What do we do when the going gets tough?

How do we treat each other, our partners, and our patients?

How do we focus and prioritize?

Our Core Values, which answer these questions, are what we at Neon choose to live by every day.

Patients

Urgently develop life-changing medicines

People

Listen | Learn | Teach

Science

Creative | Rigorous | Uncompromising

Tenacity

Persevere | Build Neon to last

Pioneer

Leave the comfort zone | Create the future

Integrity

Do RIGHT

Working at Neon

How would we describe our culture?
Here’s what our people have to say:


There’s a palpable sense of togetherness, communication and support of each other as we aim for nothing short of changing the paradigm for the treatment of cancer.  – Matt Goldstein, Director of Translational Medicine

I joined Neon to work with an incredible team who are single-mindedly focused on tackling cancer and providing patients with cutting edge personalized treatment that will revolutionize cancer care. The fun, the excitement, the promise . . .  – John Curran, Director of Sequencing Operations

I believe that we have the unique opportunity to offer patients hope by building an outstanding company, with an elite team that genuinely cares about each other.  – Diana Cassidy, Office Manager

Neon provides a rare opportunity to merge cutting-edge science with innovative therapeutic approaches. People here are all focused on this goal.  – Joel Greshock, Senior Director of Translational Bioinformatics

This is a unique opportunity to change how we treat cancer with amazing, creative people who want to make this happen.  – Kelledy Manson, VP of Product Development

We are redefining innovation to change the landscape of cancer treatment. Every day R&D works together to get closer to this goal. The collaboration between our bench and operational people is fantastic!  – Melinda Snyder, Associate Director of Clinical Operations

At Neon, we are so excited to be working on personalized cancer vaccines that have the potential to offer new treatment for cancer patients. Being part of this team is truly a unique and inspiring experience.  – Jesse Dong, VP of Peptide Chemistry

Neon aspires to be the leader in neoantigen-based therapies, which is an incredibly exciting field moving incredibly fast. In fact, it feels like we’re on a rocket ship. Career opportunities are rare where you can be part of a team that has a real chance to capitalize on new scientific insights that can immediately be translated into helping patients. Neon is one of those opportunities. We work hard, have intense discussions and also have a lot of laughs here.  – Zach Taylor, Director of Business Development & Strategy

Staffing Firms: Neon is not responsible for paying fees for candidates whose resumes are unsolicited.

Neon Therapeutics provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, or genetics. In addition to federal law requirements, Neon Therapeutics complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.